Motorists are urged to slow down, and be cautious as there is a car engulfed in flames along Nanango Brooklands Road.
Three Queensland Fire Department crews are on scene, as a vehicle has collided with a tree and caught alight.
The collision and subsequent fire were called in at 11.05am, Tuesday 5 November.
A QFD spokesperson said the car is completely involved in fire, and a grass fire was started around the area.
Queensland Ambulance spokesperson said the two patients in the vehicle have sustained life-threatening injuries.
The grass fire was contained at 11.25am, however it seems the car is still engulfed in flames.
Updates to follow.